Letter to Shareholders

November 7, 2025

The Management Board of Medinice S.A. wishes to provide current information on the current activities of the Company and the upcoming Extraordinary General Meeting of Shareholders convened on December 3, 2025.

On November 6, 2025, the Extraordinary General Meeting of Shareholders of Medinice S.A. was held, the subject of which was the vote on the resolution to increase the share capital by issuing shares through a private subscription with the exclusion of the right to subscribe.

The Company convened the Meeting in accordance with the applicable regulations, however the number of shares registered by shareholders did not reach the required quorum. According to the Commercial Companies Code regulations, a quorum of at least 1/3 of the share capital was required for the validity of this resolution.

We emphasize that the above situation does not affect the implementation of the investment agreement with the investment fund, about which the Company informed in the current report ESPI No. 32/2025 dated October 9, 2025. The consequence of the lack of quorum is only the need to convene a subsequent General Meeting, which will take place on December 3, 2025. It is worth noting that at this Meeting – in accordance with the Commercial Companies Code regulations – quorum will not be required. The provisions of the agreement remain in force, and the parties commit to their implementation.

The entire Medinice Team remains fully committed to the further development of the Company’s key projects and to commercialization activities in accordance with the strategy adopted by the Management Board.

The Management Board of Medinice S.A. plans to organize an investor meeting summarizing the most important achievements and events of the past year. We will inform you about the details in a separate announcement.

Thank you for your trust and continued support in the Company’s development.

Sincerely,

The Management Board of Medinice S.A.